![]() ![]() “Dramatic inhibition of amiodarone metabolism induced by grapefruit juice.” British journal of clinical pharmacology 49, no. “Grapefruit juice substantially increases plasma concentrations of buspirone.” Clinical Pharmacology & Therapeutics 64, no. “The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients.” Clinical Pharmacology & Therapeutics 57, no. Hollander, Adrianus AMJ, Jeroen Rooij, Eef GWM Lentjes, Francis Arbouw, Joost B. “Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats.” Pharmaceutical research 18, no. ![]() “Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.” British journal of clinical pharmacology 60, no. 5 (1998): 477-483.Īndo, Hitoshi, Shuichi Tsuruoka, Hayato Yanagihara, Koh‐ichi Sugimoto, Masaaki Miyata, Yasushi Yamazoe, Toshinari Takamura, Shuichi Kaneko, and Akio Fujimura. “Grapefruit juice-simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors.” Clinical Pharmacology & Therapeutics 64, no. Grapefruit Juice and Medicine May Not Mix. “Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice.” Chemical research in toxicology 11, no. 19 20 As long as you’re careful about not mixing them with certain types of medications, you don’t really have to worry about the side effects. They are rich in vitamin A and C, potassium, and a host of other beneficial compounds like lycopene (antioxidant) and naringin (flavonoid). Grapefruits are a great food to add to your diet. ![]() If you have been asked to avoid grapefruit, it’s best to also avoid seville oranges (used to make orange marmalade), tangelos (a cross between tangerines and grapefruit), limes, and pomelos. Other Fruits That Have Similar Side Effectsįuranocoumarins, the compound in grapefruit that’s responsible for drug reactions, is also present in few other fruits belonging to the citrus family. If you have been asked to avoid grapefruit by your doctor, check the labels on fruit juice bottles and flavored drinks to ensure they don’t contain grapefruit.If you’re taking non-prescription drugs, read the Drug Facts label to find out if you are required to avoid grapefruit or other fruit juices.Read through your patient information sheet or medication guide to check if there is a mention of grapefruit in the list of foods to avoid when taking prescription drugs.In case you cannot, check for other juices that you need to avoid. Talk to your doctor about having fresh grapefruit or grapefruit juice when you’re on medication.Safety Tips To Avoid Side Effects Of Grapefruit 17 So if you have a history of citrus allergy, it’s recommended that you avoid grapefruit along with other fruits from the citrus family. Allergic reactions to profilin are intensified when exposed to airborne allergens like grass pollen. 16 Studies have also shown that there is a connection between allergens in food and those in the air. Citrus allergy has been reported to orange, mandarin, and grapefruit, but contrary to the name of the allergy, it’s not caused by citric acid.Ĭitrus allergy is caused by immune responses to lipid transfer proteins known as profilin and pectin. In severe cases, an allergic reaction could cause anaphylaxis, a potentially life‑threatening reaction that requires immediate medical attention. If you are allergic to a particular citrus fruit, it’s highly likely that others too can trigger an allergic reaction. Grapefruit belongs to the family of citrus fruits which also include limes, lemons, and oranges. If you’re taking drugs that fall under any of the above categories, talk to your doctor about alternatives. Also, you might not have to give up grapefruit just yet as it does not react with all the drugs in a given category. Since grapefruit interferes with the metabolic process of drug absorption, its side effects are usually limited to drugs taken orally. While grapefruit makes other drugs more potent, in the case of fexofenadine, it decreases the absorption making the drug less effective. Fexofenadine: This drug is an antihistamine used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria.Just a single glass of grapefruit juice has been found to increase the concentration of this drug. Amiodarone: This drug is an antiarrhythmic medication used to treat and prevent several of types of irregular heartbeats.Having grapefruit juice considerably increases buspirone concentrations. Buspirone: It is used to treat symptoms of anxiety, such as fear, tension, irritability, and dizziness. ![]()
0 Comments
Leave a Reply. |